detox_2_600

Detox II™

$69.49

Detox II™ contains sulforaphane glucosinolate (SGS) from broccoli seed extract. It activates the body’s natural detoxification and antioxidant enzymes, protecting cells from free radical damage.

120 Vegetable Capsules

Product Description

It was first discovered in 1992 at Johns Hopkins University, being responsible for the correlation between diets rich in cruciferous vegetables and a lower incidence of cancer. One capsule of Detox II™ contains 30 mgs of SGS, which is equivalent to 1/3 pound of broccoli, in one capsule. Detox II™ also protects against harmful microbes, including H. Pylori and protects against age-related inflammation of the entire body.

Clinical Applications

  • Chemoprotective
  • Protection against G.I. Damage by H Pylori
  • Supports Eye Health
  • Blood Pressure, CV Inflammation
  • Joint Health

Discussion

Sulforaphane an isothiocyanate, is a compound that was isolated and identified in 1992 by researchers and is likely reason for the well-documented epidemiological evidence that diets rich in cruciferous vegetables, especially broccoli, may reduce the risk of cancer. Sulforaphane glucosinolate (SGS™), the precursor of sulforaphane, is present in cruciferous vegetables and especially rich in certain varieties of broccoli and broccoli sprouts. Isothiocynates are plant secondary metabolites. That is, when the plant is cut or chewed the glucosinolates are enzymatically broken down into sulforaphane and other biologically-active compounds. The greatest amount of sulforaphane glucosinolate is present when broccoli plants are just two or three days old. Broccoli sprouts (as they are called at this growth stage) contain about 250 mg of sulforaphane glucosinolate per 100 grams. Glucosinolates ingested directly without enzymatic hydrolysis are converted to isothiocyanates by the intestinal microflora.

Isothiocyanates are of particular interest due to their role in the prevention of cancer and other chronic and degenerative diseases. Laboratories worldwide have extensively studied the beneficial effects of sulforaphane, sulforaphane glucosinolate (SGS), broccoli and broccoli sprouts resulting in over 500 journal publications. The observed pattern of cancer risk reduction indicates that the breakdown products of glucosinolates may decrease the amount of DNA damage and cell proliferation, as well as block the processes that inhibit apoptosis and stimulate unregulated cell growth. These compounds are considered mono-functional modulators. They upregulate Phase 2 mammalian detoxification enzymes without upregulating Phase 1, carcinogen-producing enzymes. SGS may be referred to as an “indirect antioxidant” because the body’s own Phase 2 detoxication enzymes provide broad-spectrum antioxidant activity that may last for several days after the SGS has been consumed. Animal studies show SGS protects multiple organs from chemically-induced cancers. Many of the cancer-prevention studies have used natural preparations containing the amount of SGS equivalent to that in a single capsule of Detox II™. Unlike direct antioxidants, such as vitamins C and E, it is very unlikely that SGS could become a prooxidant. The ability of sulforaphane to induce Phase 2 enzymes may also account for its possible benefit for arthritic joints. These enzymes seem to prevent the activation of the inflammatory COX-2 enzyme.

Sulforaphane has been found to be a potent bacteriostatic agent against three reference strains and 45 clinical isolates of H. pylori, irrespective of their resistance to conventional antibiotics. SGS™ activates antioxidant enzymes in the gastric mucosal that prevent H. pylori DNA-induced damage.

HPMC hydroxypropylmethylcellulose, the highly purified, hypo-allergenic, non-GMO form of cellulose that is physiologically inert constitutes the capsules in which Detox II™ is contained.

References

1. SGS™ Fact Sheet, Brassica Protection Products LLC Baltimore, MD
2. Shapiro TA, Fahey JW, Wade KL, Stephenson KK, Talalay P. Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans. Cancer Epidemiol Biomarkers Prev. 2001 May;10(5):501-8.
3. Fahey JW, Zhang Y, Talalay P. Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proc Natl Acad Sci 1997;94:10367–72.
4. Nestle M. Broccoli sprouts as inducers of carcinogen-detoxifying enzyme systems: clinical, dietary, and policy implications. Proc Natl Acad Sci 1997;94:11149–51 [review].
5. Zhang Y, Kensler TW, Cho CG, Posner GH, Talalay P. Anticarcinogenic activities of Sulforaphane and structurally related synthetic norbornyl isothiocyanates. Proc. Natl. Acad. Sci. USA, 1994; Apr91:3147-3150.
6. Zhang Y, Talalay P, Cho CG, Posner G. A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc. Natl. Acad. Sci. USA, 1992; Mar 89:2399-2403
7. Jackson SJ, Singletary KW. Sulforaphane inhibits human MCF-7 mammary cancer cell mitotic progression and tubulin polymerization. J Nutr. 2004 Sep;134(9):2229-36.[ PMID: 15333709]
8. Chiao JW, Wu H, Ramaswamy G, Conaway CC, Chung FL, Wang L, Lui D. Ingestion of an isothiocyanate metabolite from cruciferous vegetables inhibits growth of human prostate cancer cell xenographs by apoptosis and cell cycle arrest. Carcinogenesis 2004; 25(8):1403-1408 [PMID:15016658]
9. Fahey JW, Haristoy X, Dolan PM, Kensler TW, Scholtus I, Stephenson KK, Talalay P, Lozniewski A. Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors. Proc Natl Acad Sci USA. 2002 May 28;99(11):7610- [PMID: 12032331]
10. Yanaka, A. Broccoli Sprouts Relieve Gastritis in H. pylori Patients: May Help Prevent Gastric Cancer (Abstract #3442) American Institute for Cancer Research Annual Meeting. Baltimore, MD, Poster Session: 7:30 a.m. Nov 2, 2005
11. Gao X, Talalay P. Induction of Phase 2 genes by sulforaphane protects retinal pigment epithelial cells against photooxidative damage . Proc Natl Acad Sci USA 2004 July 101 (28): 10446-10451 [www.pnas.org/cgi/doi/10.1073/pnas.0403866101]
12. Wu L, et al. Dietary approach to attenuate oxidative stress, hypertension, and inflammation on the cardiovascular system. 2004, May 101(18):7094-7099 [www.pnas.org/cgi/doi/10.1073/pnas.0402004101
13. Healy Z, et al. Proceedings of the National Academy of Sciences 2005, Sept: 102(39): 14010-14025,
14. http://www.broccosprouts.com/health/sgsfactsheet.htm {Accessed 11.4.05}
15. Kall MA, Vang O, Clausen J. Effects of dietary broccoli on human drug metabolizing activity. Cancer Lett 1997;114:169–70.
16. Zhang Y, Tang L. Discovery and development of sulforaphane as a cancer chemopreventive phytochemical Acta
Pharmacologica Sinica 2007 September; 28 (9): 1343-1354.

These statements have not been evaluated by the FDA. This product is not intended to treat, diagnose, prevent, or cure any disease. Consult a physician before taking. Should you experience any serious physical side effects from taking these nutritional supplements, discontinue and call your doctor immediately.

Additional Information

Weight 1 lbs

Dosage

Take one to capsules capsules once or twice daily or as directed by your healthcare practitioner.

Contraindications

At the time of this writing there have not been any side effects or drug interactions reported. However, since
sulforaphane does interact with drug detoxifying enzymes, individuals taking prescription drugs deserve close
evaluation and supervision.