resveratrol

Resveratrol™

$64.37

Dr. Ramsey’s Resveratrol™ is a bioflavonoid complex containing three synergistic antioxidants: pterostilbene, resveratrol and quercetin. This combination specifically enhances absorption and half life of resveratrol making it a very stable compound.

60 Capsules

Product Description

Dr. Ramsey’s Resveratrol™ is a bioflavonoid complex containing three synergistic antioxidants: pterostilbene, resveratrol and quercetin. This combination specifically enhances absorption and half life of resveratrol making it a very stable compound. These three compounds are being studied extensively in the areas of cardiovascular health, cell replication, capillary integrity and anti-aging.

Discussion

Resveratrol (RES) (3,5,4’-trihydroxystilbene) is a stilbenol derived from stilbene, a natural plant product. RES is found in varying amounts in grapes, various berries, plums, peanuts (and pines). Oral resveratrol is rapidly metabolized via sulfate conjugation by the intestine/liver.(1) The methyl capping of all free hydroxyl groups (as in Pterostilbene) results in dramatically higher hepatic metabolic stability, intestinal absorption and membrane transport compared to unmethylated RES.(2,3) Quercitin, pterostilbene and resveratrol are synergistic antioxidants, with quercitin seemingly aiding in the absorption of resveratrol.(4)

Stilbenols are polyphenolic compounds that are chemoproventive.(5) As a chemo-preventive agent, RES has mostly been linked to growth and death regulatory pathways. Research published in 2008 also demonstrated resveratrol’s contribution to the maintenance of genome stability. Resveratrol interferes with all three stages of carcinogenesis – initiation, promotion and progression. It can potentially modulate cell death, as well as cell cycle and estrogen receptor function in breast cancer cell lines.(6) Pterostilbene and quercetin, structurally related and naturally-occurring, small polyphenols, show longer half-life in vivo than unmethylated resveratrol and have been shown to synergistically be chemoprotective.(7)

As exciting as its role in chemoprotection, is resveratrol’s ability to produce changes associated with longevity. These include increased insulin sensitivity, reduced IGF-1, increased AMP-activated protein kinase and peroxisome proliferator-activated receptor-gamma coactivator 1 alpha activity, increased mitochondrial number and improved motor function. Resveratrol opposed the effects of the high calorie diet in 144 of 153 significantly altered gene pathways.(8) Resveratrol activates sirtuins including SIR2, a special longevity cellular enzyme (9) and SIRT1 that affords protection against neuronal degeneration. (10) In vitro, ex vivo and animal experiments have shown that the attributes of RES such as its powerful antioxidant activity, modulation of hepatic apolipoprotein and lipid synthesis, inhibition of platelet aggregation, and human platelet and neutrophil production of pro-atherogenic eicosanoids favor protection against atherosclerosis.(11)

Resveratrol numerous anti-inflammatory properties may explain why it has so many far-reaching healthbenefits. It inhibits synthesis and release of pro-inflammatory mediators, modifies eicosanoid synthesis,and inhibits activated immune cells. By inhibiting either NF-(kappa)B or the activator protein-1 (AP-1),resveratrol also appears to inhibit inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).12 Specific human dosing to obtain an anti-inflammatory effect has not yet been established.(13)

References

1. Wenzel E, Somoza V. Metabolism and bioavailability of trans-resveratrol. Mol Nutr Food Res. 2005 May;49(5):472-81. [PMID:15779070]
2. Walle T, et al. High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Dispos. 2004 Dec;32(12):1377-82. [PMID:15333514]
3. Wen X, Walle T. Methylated flavonoids have greatly improved intestinal absorption and metabolic stability. Drug Metab Dispos. 2006 Oct;34(10):1786-92 [PMID: 16868069]
4. Morimitsu Y, Sugihara N, Furuno K. Inhibitory effect of flavonoids on sulfo- and glucurono-conjugation of acetaminophen in rat cultured hepatocytes and liver subcellular preparations. Biol Pharm Bull. 2004 May;27(5):714-7. [PMID: 15133252]
5. Fresco P, Borges F, Diniz C, Marques MP. New insights on the anticancer properties of dietary polyphenols. Med Res Rev. 2006 Nov;26(6):747-66 [PMID: 16710860]
6. Whitsett TG Jr, Lamartiniere CA. Genistein and resveratrol: mammary cancer chemoprevention and mechanisms of action in the rat. Expert Rev Anticancer Ther. 2006 Dec;6(12):1699-706. [PMID: 17181483]
7. Ferrer P, et al.Association between pterostilbene and quercetin inhibits metastatic activity of B16 melanoma. Neoplasia. 2005 Jan;7(1):37-47. [PMID:15736313]
8. Baur JA, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 2006 Nov 16;444(7117):337-42. [PMID: 17086191]
9. Stefani M, et al. The effect of resveratrol on a cell model of human aging. Ann NY Acad Sci. 2007 Oct;1114:407-18. [PMID: 17804521]
10. Tang BL, Chua CESIRT1 and neuronal diseases. Mol Aspects Med. 2007 Feb 16 [PMID: 17397914]
11. Soleas GJ, Diamandis EP, Goldberg DM. Resveratrol: a molecule whose time has come? And gone? : Clin Biochem. 1997 Mar;30(2):91-113 [PMID:9127691]
12. de la Lastra CA, Villegas I.Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications. Mol Nutr Food Res. 2005 May;49(5):405-30 [PMID:15832402]
13. Hougee S, Faber J, Sanders A, de Jong RB, van den Berg WB, Garssen J, Hoijer MA, Smit HF. Selective COX-2 inhibition by a Pterocarpus marsupium extract characterized by pterostilbene, and its activity in healthy human volunteers. Planta Med. 2005 May;71(5):387-92. [PMID: 15931573]

These statements have not been evaluated by the FDA. This product is not intended to treat, diagnose, prevent, or cure any disease. Consult a physician before taking. Should you experience any serious physical side effects from taking these nutritional supplements, discontinue and call your doctor immediately.

Additional Information

Weight 1 lbs

Dosage

Take one capsule twice a day or as directed.