Tum Ease™ not only relieves symptoms, it heals cells that have been stressed and damaged.
- Relieve Gastric Discomforts (e.g. upset stomach, belching, burping, bloat, episodes of indigestion, mild nausea)
- Support Healthy Balance of G.I. Flora
- Protect and Support the Integrity of the Gastric Mucosa
- Provide Antioxidant Protection for Gastric cells
- Inhibit Inflammatory Cytokine Expression in Gastric Cells
A wide range of treatments exist for the approximately 25-40% of Americans who suffer from symptoms related to dyspepsia. Commonly used antacids and anti-inflammatory drugs like NSAIDS used regularly impact digestion and the mucosal lining, resulting in a gastric environment friendly to a specific problematic bacterial strain.1 Whereas common stomach health products either neutralize or block gastric acid, Tum Ease™ supports the stomach’s natural “cytoprotective” defense mechanisms. In human studies among 691 subjects, including clinical trials that showed improvement in endoscopic healing rates at both 4 and 8-week time points, zinc-carnosine exhibited high efficacy without any serious side effects.2
Carnosine is a naturally-occurring di-peptide composed of the amino acids, L-histidine and ß-alanine. Carnosine can form stable complexes (ligands) with ion minerals like zinc and copper. Tum Ease™ contains a unique, patented zinc L-carnosine complex that has been in wide clinical use in Japan since 1994. Tum Ease™ differs chemically and biologically from a simple combination of zinc and L-carnosine and has been shown to be be approximately three times more effective than supplementing with either zinc sulfate or L-carnosine individually.3
The healthy gastric mucosal lining protects the stomach unless it is overburdened by the damaging effects of stress, bacteri or irritating substances. Carnosine and zinc each have wound-healing properties; therefore it is not surprising that the zinc L-carnosine ligand significantly protects and has been shown to heal the gastric lining, re-establishing balance within the stomach in a short time frame.4,5
Zinc L-carnosine complex does not rapidly breakdown in the stomach juice because it is a polymer. Japanese researchers found that this prolonged-release complex adheres to damaged areas of the stomach lining and forms a new mixed ligand complex with other body components (perhaps proteins, like albumin) at the site of the damage. At some point, a ligand exchange takes place freeing the L-carnosine and zinc from the complex and making each available to support the healing process.6 L-carnosine combats free radicals7 and zinc reduces inflammation.8 Animal studies have demonstrated the zinc-carnosine complex maintains the homeostasis of the gastric mucosa not only by promoting repair of damaged tissue,9 but also by its anti-oxidative, membrane-stabilizing capability10 and by protecting gastric cells via promotion of mucous production.11 The zinc-carnosine complex also blunts genetic pro-inflammatory signaling and of the release of pro-inflammatory cytokine expression in the gastric epithelial cells.12
This complex has been shown to have selective anti-bacterial activity against a specific common strain known to weaken the gastric mucosa.6 The anti-urease activity of the complex may be responsible for its effect upon this bacteria.
1. Sanduleanu S, et al. Double gastric infection with Helicobacter pylori and non-Helicobacter pylori bacteria during acid-suppressive therapy: increase of pro-inflammatory cytokines and development of atrophic gastritis. Aliment Pharmacol Ther. 2001 Aug;15(8):1163-75 [PMID: 11472319]
2. Compilation of numerous studies presented in Jpn Pharmacol Ther 1992;(20)1
3. Korolkiewicz RP, et al. Polaprezinc exerts a salutary effect on impaired healing of gastric lesions in diabetic rats. Dig Dis Sci 2000;45(6):1200-1209
4. Nishiwaki H, Kato S, Sugamoto S, et al. Ulcerogenic and healing impairing actions of monochloramine in rat stomachs: effects of zinc L-carnosine, polaprezinc. J Physiol Pharmacol 1999;50:183-95.
5. Arakawa T, Satoh H, Nakamura A, et al. Effects of zinc L-carnosine on gastric mucosal and cell damage caused by ethanol in rats. Correlation with endogenous prostaglandin E2. Dig Dis Sci 1990;35:559-66.
6. Matsukura T, Tanaka H. Applicability of zinc complex of L-carnosine for medical use. Biochemistry (Mosc). 2000 Jul;65(7):817-23 [PMID: 10951100]
7. Carnosine and carnosine-related antioxidants: a review. Curr Med Chem. 2005;12(20):2293-315 [PMID: 16181134]
8. Sempértegui F, Díaz M, et al. Low concentrations of zinc in gastric mucosa are associated with increased severity of Helicobacter pylori-induced inflammation. Helicobacter. 2007 Feb;12(1):43-8 [PMID: 17241300]
9. Seiki M. et al. [Effect of Z-103 on wound healing by dermal incision in guinea pigs] Nippon Yakurigaku Zasshi. 1992 Aug;100(2):165-72 [PMID: 1385281]
10. Arakawa, T., Satoh, H., Nakamura, A., Nakamura, H., Ishikawa, M., and Kobayashi, K. (1988) Gastroenterology, 94, A12
11. Arakawa T, et al. Effects of zinc L-carnosine on gastric mucosal and cell damage caused by ethanol in rats. Correlation with endogenous prostaglandin E2. Dig Dis Sci. 1990 May;35(5):559-66 [PMID: 2331952 ]
12. Tadahito Shimada, et al. Polaprezinc down-regulates pro-inflammatory cytokine-induced Nuclear Factor- B activation and Interleukin-8 Expression in gastric epithelial cells . J Pharmacol Ther 1999; 291(1); 345-352
13. See ref #6
14. Kashimura H, et al. Polaprezinc, a mucosal protective agent, in combination with Iansoprazole, Amoxycillin and Clarithromycin increases the cure rate of Helicobacter pylori infection. Aliment Pharmacol Ther 1999;13:483-487
These statements have not been evaluated by the FDA. This product is not intended to treat, diagnose, prevent, or cure any disease. Consult a physician before taking. Should you experience any serious physical side effects from taking these nutritional supplements, discontinue and call your doctor immediately.